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yinzhijiedukeli for swine circovirus infection uses

  • Porcine Circovirus 2 Uses a Multitude of Weak Binding ...

    Porcine circovirus 2 (PCV2) is the smallest pathogenic virus capable of autonomous replication within its host. Infections result in immunosuppression and subsequent death of the host and are initiated via the attachment of the PCV2 icosahedral capsid to heparan sulfate (HS) and chondroitin sulfate B (CSB) glycosaminoglycans on the cell surface.

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  • Porcine circovirus 2 (PCV2) induces a procoagulant

    2010-2-24 · Considering the key role played by thrombin in hemostasis and other physiological processes, linked with the fact that thrombin plasma activity is more expressive in swine with PCVD, with the importance of the endothelium in the PCV2 infection and with the reported viral infections in which coagulation activation and enhanced thrombin activity are associated to an increase in viral infectivity …

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  • The application of molecular methods in the

    2016-1-1 · Porcine circovirus 2 (PCV2) belongs to the family Circoviridae, genus Circovirus. Infection of swine caused by this virus is manifested in several different clinical forms, leading to significant economic losses in swine production worldwide. For this reason, prompt and precise diagnostics of this swine infection is of great importance.

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  • Porcine Circovirus Cap-Induced Apoptosis of Non

    2019-7-18 · Porcine Circovirus 2 (PCV2) is a pathogen of major importance for swine production around the world. Despite development of several vaccines and robust vaccination programs, PCV2 continues to persistently transmit within and between swine herds causing infections marked by immunosuppression via lymphocyte depletion.

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  • First report of porcine circovirus type 2 infections in

    The PCR analysis showed that 67.7% of the samples (23/34) from seven swine herds of six different geographic regions were detected to be positive for PCV2. Ten of the 23 PCV2 positive samples (43.5%) shown a concurrent infection with porcine parvovirus porcine …

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  • Cell tropism and entry of porcine circovirus 2 -

    2012-3-1 · Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells

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  • Prevalence of infection with porcine circovirus-2 (PCV

    The objective of this study was to evaluate the prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) through a longitudinal study in an integrated swine production system (7 farms) experiencing postweaning multisystemic wasting …

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  • Mouse models of porcine circovirus 2 infection -

    2018-4-19 · The results showed that mice treated with atorvastatin during PCV2 infection had reduced body weights. 18 PCV2 antigens were mainly immunolocalized to the cytoplasms and plasma membranes of cells in the lymph nodes of PCV2‐inoculated mice. 18 These results further confirmed that HMGCR is negatively associated with PCV2 infection. 64, 18 Furthermore, CD44 has been reported to play an antiviral role in response to PCV2 infection…

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  • Epidemiological, clinical and anatomopathological

    Porcine circovirosis is a disease of viral etiology, with special significance in the intensive farming of pigs. The investigations were conducted during 2007-2009 in three swine farms, in the Western part of country, where it was pursued the presence of PCV2 infection by epidemiological, clinical and anatomopathological examinations.

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  • Infection studies on human cell lines with porcine ...

    2004-4-19 · A replication assay showed that the replication of PCV DNA was initiated at the origin of replication. When virus‐free cells were inoculated with the supernatant of PCV‐infected human cells, the infection was not passed. Conclusion: Although PCV gene expression and replication took place in human cells, the infection is non‐productive. Alteration of protein localization suggests that protein …

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  • Porcine circovirus 2 (PCV2) induces a procoagulant

    2010-2-24 · Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells. J. Virol., 80 (2006), ... African swine fever virus infection of porcine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state, and apoptosis.

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  • Porcine Circovirus Cap-Induced Apoptosis of Non

    2019-7-18 · Porcine Circovirus 2 (PCV2) is a pathogen of major importance for swine production around the world. Despite development of several vaccines and robust vaccination programs, PCV2 continues to persistently transmit within and between swine herds causing infections marked by immunosuppression via lymphocyte depletion.

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  • Fast diagnosis and quantification for porcine

    Background/Purpose: The postweaning multisystemic wasting syndrome, caused by the porcine circovirus type 2 (PCV-2), is a major disease that poses a significant threat to the global swine industry. The purpose of this study was to establish a real-time polymerase chain reaction (PCR) method for the quantification of PCV-2 and to enable the rapid differentiation of porcine circoviruses type 1 ...

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  • Clinical and anatomopathological research in porcine ...

    Porcine circovirosis is a disease of viral etiology, with special significance in the intensive farming of pigs. The investigations were conducted during 2007-2009 in three swine farms, in the Western part of country, where it was pursued the presence of PCV2 infection by clinical and anatomopathological examinations. During the research, in the herds of these three farms it was reported only ...

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  • Prevalence of infection with porcine circovirus-2 (PCV

    The objective of this study was to evaluate the prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) through a longitudinal study in an integrated swine production system (7 farms) experiencing postweaning multisystemic wasting syndrome (PMWS). Risk factors for PCV-2 infection and for PCV-2 and PRRSV coinfection were also...

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  • Development and validation of a real-time PCR for the ...

    2018-8-27 · Keywords Porcine circovirus Swine Real-time PCR qPCR TaqMan probe Introduction Classified within the genus Circovirus of the Circoviridae family, porcine circovirus type 2 (PCV2) was initially identified in a Canadian swine herd in 1991, and since then, has been implicated as the etiological agent of postweaning

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  • First report of porcine circovirus type 2 infections in

    To obtain information about the porcine circovirus type 2 (PCV2) infection status of pigs in Cuba and the probable association of PCV2 with other porcine viruses, tissue samples collected from ill pigs were evaluated using polymerase chain reaction (PCR). The PCR analysis showed that 67.7% of the samples (23/34) from seven swine herds of six different geographic regions were detected to be...

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  • Differential Proteome Analysis of Host Cells Infected

    2021-3-13 · Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome, which is an emerging swine immunosuppressive disease. To uncover cellular protein responses in PCV2-infected PK-15 cells, the comprehensive proteome profiles were analyzed utilizing two-dimensional gel electrophoresis (2-DE) coupled with MALDI-TOF/TOF …

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  • Production of a monoclonal antibody against Porcine ...

    2018-11-1 · Porcine cirvovirus type 3 (PCV3) is a newly emerging swine virus with worldwide distribution. The pathogenesis of PCV3 remains unknown due to failures in propagating and isolating the virus on successive cell lines. The virus cap protein is the only structural protein of PCV3 and no monoclonal antibodies against it are available.

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  • WO2005092069A2 - Chimeric infectious dna clones,

    The disclosure relates to infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PÇVl in which the immunogenic ORF gene of the pathogenic …

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  • Co-Infection of Swine with Porcine Circovirus - ProQuest

    Explore millions of resources from scholarly journals, books, newspapers, videos and more, on the ProQuest Platform.

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  • EP 3388515 A1 20181017 - CHIMERIC INFECTIOUS

    499809081 - EP 3388515 A1 20181017 - CHIMERIC INFECTIOUS DNA CLONES OF PORCINE CIRCOVIRUS AND USES THEREOF - The present invention relates to an immunogenic polypeptide product which is obtainable by expressing infectious chimeric DNA clones of porcine circovirus (PCV). The present invention also relates to corresponding vaccines and means of protecting pigs against viral infection …

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  • Co-Infection of Swine with Porcine Circovirus Type 2

    2021-7-3 · Strategies, Plans & Capacity Development. National Action Plan for Health Security (NAPHS) Covid-19 Socio-Economic Plan

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  • Co-infection of swine with porcine circovirus type 2

    Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication of other pathogens.

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  • Co-Infection of Swine with Porcine Circovirus Type 2

    Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses Ting Ouyang, Xinwei Zhang, Xiaohua Liu, Linzhu Ren; Affiliations Ting Ouyang Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin …

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  • Sparrho | Porcine circovirus type 2 (PCV2) infection ...

    2011-12-2 · Porcine circovirus type 2 (PCV2) infection decreases the efficacy of an attenuated classical swine fever virus (CSFV) vaccine. Research paper by Yu-Liang YL Huang, Victor Fei VF Pang, Chun-Ming CM Lin, Yi-Chieh YC Tsai, Mi-Yuan MY Chia, Ming …

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  • Table 3 from Porcine circovirus type 2 (PCV2) infection ...

    Table 3 Changes in the number of pigs developing porcine circovirus type 2 (PCV2) and wild-type classical swine fever virus (CSFV) viremia in various treatment groups over time after CSFV challengea. - 'Porcine circovirus type 2 (PCV2) infection decreases the efficacy of an attenuated classical swine fever virus (CSFV) vaccine'

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  • Subclinical and clinical circoviral infection of swine ...

    The paper is presenting basic data about circoviruses of swine and subclinical infection or disease they alternatively may cause. PCV1 is mentioned as being non pathogenic. Much more in detail is characterized the PCV2, being at present evaluated as one of the most important pathogenic viruses of swine. The virus is subdivided into genotypes of which PCV2a and PCV2b are the most pathogenic...

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  • Differential Proteome Analysis of Host Cells Infected

    2021-3-13 · Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome, which is an emerging swine immunosuppressive disease. To uncover cellular protein responses in PCV2-infected PK-15 cells, the comprehensive proteome profiles were analyzed utilizing two-dimensional gel electrophoresis (2-DE) coupled with MALDI-TOF/TOF …

    Get Price
  • Development and validation of a real-time PCR for the ...

    2018-8-27 · Keywords Porcine circovirus Swine Real-time PCR qPCR TaqMan probe Introduction Classified within the genus Circovirus of the Circoviridae family, porcine circovirus type 2 (PCV2) was initially identified in a Canadian swine herd in 1991, and since then, has been implicated as the etiological agent of postweaning

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  • Successes and challenges in the developmemt of

    2018-4-6 · Swine influenza virus (SIV) and porcine circovirus type 2 (PCV2) are two of the disease agents commonly associated with PRDC [4;9]. Although SIV is considered a secondary infection in the etiology of PRDC, recent reports of persistence in swine herds suggest an

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  • Porcine Circovirus 2 Uses Heparan Sulfate and

    2020-12-22 · Monocyte/macrophage lineage cells are target cells in vivo for porcine circovirus 2 (PCV2) replication. The porcine monocytic cell line 3D4/31 supports PCV2 replication in vitro, and attachment and internalization kinetics of PCV2 have been established in these cells. However, PCV2 receptors remain unknown. Glycosaminoglycans (GAG) are used by several viruses as receptors. The present study ...

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  • Interaction of Porcine circovirus 2 with the Swine Immune ...

    2018-1-17 · ii Abstract Porcine circovirus 2 (PCV2) is a virus with a single-stranded, DNA circular genome that is ubiquitous in pig populations worldwide. PCV2 is the causative agent of the post-weaning multisystemic wasting syndrome (PMWS), a multifactorial disease that affects six to twelve-

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  • Human cells are permissive for the productive

    2011-5-3 · Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233-amino-acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection. The goal of this study was to identify regions in CP preferentially recognized by sera from experimentally infected and vaccinated pigs ...

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  • Antibody Recognition of Porcine Circovirus Type 2

    2012-11-1 · Swine samples originated from Rio Grande do Sul 31 (52%), Santa Catarina 14 (23%), Paraná 11 (18%), and Mato Grosso do Sul 4 (7%). Positive anti-IA IHC labelling was observed in 45% of the cases, which were associated with necrotizing bronchiolitis, atelectasis, purulent …

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  • Histopathological and immunohistochemical findings

    Porcine circovirus type 2 (PCV2) belongs to the viral family Circoviridae and to the genus Circovirus. Circoviruses are small, single‐stranded nonenveloped DNA viruses that have an unsegmented circular genome. PCV2 is the primary causative agent of several syndromes collectively known as porcine circovirus‐associated disease (PCVAD).

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  • Porcine Circovirus Type 2 and Porcine Circovirus ...

    2021-3-12 · Viral infections usually result in alterations in the host cell proteome which determine the fate of the infected cells and the progress of pathogenesis. To uncover cellular protein responses in classical swine fever virus-infected PK-15 cells, a proteomic analysis was conducted using 2D PAGE followed by MALDI-TOF-MS/MS identification. Altered expression of 35 protein spots in infected cells ...

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  • Proteomic Alteration of PK-15 Cells after Infection by ...

    [98 Pages Report] Check for Discount on Global Swine Circovirus Vaccine Market Research Report 2021 report by QYResearch Group. The research report includes specific segments by region (country), by...

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  • Global Swine Circovirus Vaccine Market Research

    2008-9-19 · African swine fever virus belongs to the Asfarviridae family and uses a different mechanism to evade immune surveillance. Within 10 h of infection, this virus induces alteration of the secretory pathway by interfering with the trans‐Golgi network (TGN).

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  • Dendritic cells--at the front-line of pathogen attack

    The present review uses two virus examples--classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2)--to demonstrate the complexity of this host-pathogen scenario. CSFV is a monocytotropic RNA virus infecting and replicating in both cDC and pDC.

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  • Bronchiolitis Obliterans Organizing Pneumonia in

    2010-9-27 · Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.

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  • A Methodology for Porcine Circovirus 2 (PCV-2 ...

    2020-2-29 · Porcine circovirus diseases (PCVD) is one of the most important diseases a ecting domestic swine production; it is caused by porcine circovirus 2 (PCV-2) belonging to the family Circoviridae, genus Circovirus, which comprises three endemic types, PCV-1, PCV-2, and PCV-3 [1].

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  • The survey of porcine teschoviruses, porcine circovirus ...

    2012-12-7 · A multiplex PCR assay was developed and evaluated for its ability to simultaneously detect three viral infections of swine. Specific primers were carefully selected from articles published for each of the following three viruses: porcine circovirus type II (PCV2), porcine teschovirus (PTV) and porcine transmissible gastroenteritis virus (TGEV).

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  • Development and validation of a real-time PCR for the ...

    2018-7-17 · Classified within the genus Circovirus of the Circoviridae family, porcine circovirus type 2 (PCV2) was initially identified in a Canadian swine herd in 1991, and since then, has been implicated as the etiological agent of postweaning multisystemic wasting syndrome (PMWS) [].This disease of pigs is clinically characterised by growth retardation, paleness of skin, dyspnoea, enlargement of ...

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  • Porcine Circovirus 2 ในปี 2020

    Effect of porcine circovirus type 2(PCV2) infection on reproduction: disease, vertical transmission, diagnostics and vaccination. Anim. Health Res. Rev.12, 47-65-Seagales J. 2018. In the proceeding of IPVS2018., 58-59

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  • Three different genotypes of porcine circovirus 2 (PCV

    2021-3-15 · Porcine circovirus 2 (PCV-2) is the causative agent of porcine circovirus diseases (PCVD). A study was undertaken to determine whether PCV-2 was present in samples collected from commercial pigs (n = 46) and warthogs (n = 42) in Namibia between 2019 and 2020. Twenty-three of the collected samples were positive by PCR (13 from pigs and 10 from warthogs), and a phylogenetic analysis of …

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  • Immune evasion during foot-and-mouth disease virus ...

    and swine, which is characterized by vesicular lesions on the lips, tongue, snout, and coronary bands of the feet (15). Similarly, rodents are a poor model for foot-and-mouth disease virus (FMDV) infection, as infection of mice requires high doses of virus and there is no clinical vesicular disease.

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  • Disease guide | The Pig Site

    Porcine respiratory coronavirus (PRCV) Porcine Stress Syndrome (PSS) Post-weaning (spirochaetal) diarrhoea. Post-weaning multisystemic wasting syndrome (PMWS) Preputial ulceration. Prolapse of the Bladder. Prolapse of the Rectum. Prolapse of the uterus (womb) Prolapse of the Vagina and Cervix.

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  • EP1487483A2 - Chimeric infectious dna clones,

    The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2). The new chimeric infectious DNA clone and its derived, a virulent chimeric virus are constructed from the nonpathogenic PCV1 in which the ...

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  • Interaction of Porcine circovirus 2 with the Swine

    Libraries and Cultural Resources

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  • Multiplex Serology for Common Viral Infections in

    2015-1-1 · Multiplex serology was performed for the detection of total immunoglobulin (Ig) and IgM antibodies against porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and swine influenza virus (SIV) antigens in feral swine (Sus scrofa).Serum samples were collected from the islands of Oahu (292 pigs) and Hawaii (52 pigs) between 2007 and 2010.

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  • Effective method of treatment of porcine circovirus

    The present invention relates to the use of porcine circovirus type 2 (PCV2) antigen and Lawsonia intracellularis ( L. intracellularis ) antigen for the prevention, reduction in severity o Effective method of treatment of porcine circovirus and Lawsonia intracellularis infections - …

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  • Antibody Recognition of Porcine Circovirus Type 2

    2011-5-3 · Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233-amino-acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection. The goal of this study was to identify regions in CP preferentially recognized by sera from experimentally infected and vaccinated pigs ...

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  • Viruses | Free Full-Text | Porcine Circoviruses and ...

    Allotransplantation and xenotransplantation may be associated with the transmission of pathogens from the donor to the recipient. Whereas in the case of allotransplantation the transmitted microorganisms and their pathogenic effect are well characterized, the possible influence of porcine microorganisms on humans is mostly unknown. Porcine circoviruses (PCVs) are common in pig breeds and they ...

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  • Disease guide | The Pig Site

    Porcine respiratory coronavirus (PRCV) Porcine Stress Syndrome (PSS) Post-weaning (spirochaetal) diarrhoea. Post-weaning multisystemic wasting syndrome (PMWS) Preputial ulceration. Prolapse of the Bladder. Prolapse of the Rectum. Prolapse of the uterus (womb) Prolapse of the Vagina and Cervix.

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  • Reversible Mannosylation as a Covalent Binding

    2020-12-4 · Diseases assocd. with porcine circovirus type 2 (PCV2) infection are having a severe economic impact on swine-producing countries. The PCV2 capsid (Cap) protein expressed in eukaryotic systems self-assemble into virus-like particles (VLPs) which can serve as antigens for diagnostics or/and as vaccine candidates.

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  • Methods of overexpression and recovery of porcine ...

    2005-1-13 · The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex, Vaccine (2008) 26, 1488-99. Chiou, et al., The Effect of Porcine Circovirus Infection on the Immune Response of Pigs After Vaccination Against Classical Swine Fever and Pseudorabies, Proceedings of the 19th IPVS Congress.

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  • US Patent for Recombinant antigens of porcine

    2014-1-23 · The present invention relates to the preparation of the recombinant antigen of the viral capsid of Porcine circovirus 2 (PCV-2) and modifications thereof, upon expression in a prokaryotic system, purification in the monomer form, recovery of virus-like particles (VLPs) and their use in vaccine formulations, diagnostic kits and a system for quantifying in vaccine lots of the PCV-2 antigen by ...

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  • Identifying an outbreak of a novel swine disease using ...

    2012-10-16 · PRRSV infection presents with numerous and varied clinical signs in multiple age groups of pigs. This may explain why astute swine veterinarians regularly monitor client herds for PRRSV, and why swine disease outbreak investigations start with an examination for the presence of PRRSV . From a disease monitoring and surveillance point of view ...

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  • REVIEW Open Access Porcine circovirus type 2 in China:

    2017-8-26 · Chinese swine farms. The aim of this review is to update the insights into the prevalence and control of PCV2 in China, which would contribute to understanding the epidemiology, control measures and design of novel vaccines for PCV2. Keywords: Porcine circovirus type 2, Prevalence, Control, PCV2 vaccines, Update, China Introduction

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  • Development and application of a competitive

    We report the development of a competitive enzyme-linked immunosorbent assay (c-ELISA) for the detection of antibodies to porcine circovirus type 2 (PCV2), the agent associated with the recently described postweaning multisystemic wasting syndrome in …

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  • Effective method of treatment of porcine circovirus

    The present invention relates to the use of porcine circovirus type 2 (PCV2) antigen and Lawsonia intracellularis ( L. intracellularis ) antigen for the prevention, reduction in severity o Effective method of treatment of porcine circovirus and Lawsonia intracellularis infections - …

    Get Price
  • [PDF] Porcine Circovirus 2 Uses Heparan Sulfate and ...

    ABSTRACT Monocyte/macrophage lineage cells are target cells in vivo for porcine circovirus 2 (PCV2) replication. The porcine monocytic cell line 3D4/31 supports PCV2 replication in vitro, and attachment and internalization kinetics of PCV2 have been established in these cells. However, PCV2 receptors remain unknown. Glycosaminoglycans (GAG) are used by several viruses as receptors.

    Get Price
  • Probing genetic control of swine responses to PRRSV ...

    2011-6-3 · The project uses a nursery pig model to assess pig resistance/susceptibility to primary PRRSV infection. To date, 6 groups of 200 crossbred pigs from high health farms were donated by commercial sources. After acclimation, the pigs were infected with PRRSV in a biosecure facility and followed for 42 days post infection (dpi).

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  • CIRCOVIRUS PORCINO PDF - anthonyshomestudio.com

    2021-1-28 · Porcine circovirus – Wikipedia. Colostrum samples were collected immediately after parturition and one day after farrowing. Comparisons of means were conducted using Duncan’s multiple range test. Multiple porcine circovirus 2 associated abortion and reproductive failure in a multiple-site swine production unit. Seventh report of the ICTV.

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  • velopment of a TaqMan PCR assay with internal

    2015-1-15 · swine fever (CSF) outbreak were tested. These samples were also tested for CSFV by reverse-transcriptase nested TaqMan† PCR (McGoldrick et al., 1999)and for porcine circovirus-2 by TaqMan† PCR (Grierson et al., 2002 unpublished data). 2.3. Construction of an artificial template (mimic) A 537 bp fragment of ASFV encompassing the

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  • WO2016183423A1 - Method for porcine circovirus

    This invention relates to a method for rapid production of PCV2 such that an optimum yield of the virus can be obtained. This invention also relates to the vaccine useful against PCV2 which includes the PCV2 propagated using such a method.

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  • The 2.3-Angstrom Structure of Porcine Circovirus 2 ...

    2011-7-5 · Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 virus-like particle at 9.6-Å resolution. This is the first atomic structure of ...

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  • Development and application of a competitive

    We report the development of a competitive enzyme-linked immunosorbent assay (c-ELISA) for the detection of antibodies to porcine circovirus type 2 (PCV2), the agent associated with the recently described postweaning multisystemic wasting syndrome in …

    Get Price
  • Identifying an outbreak of a novel swine disease using ...

    2012-10-16 · PRRSV infection presents with numerous and varied clinical signs in multiple age groups of pigs. This may explain why astute swine veterinarians regularly monitor client herds for PRRSV, and why swine disease outbreak investigations start with an examination for the presence of PRRSV . From a disease monitoring and surveillance point of view ...

    Get Price
  • In Vitro Coinfection and Replication of Classical Swine ...

    2015-10-2 · Here, we investigated whether PCV2 and CSFV could infect the same cell productively by constructing an in vitro coinfection model. Our results indicated that PCV2-free PK15 cells but not ST cells were more sensitive to PCV2, and the PK15 cell line could stably harbor replicating CSFV (PK15-CSFV cells) with a high infection rate.

    Get Price
  • Porcine Circovirus Type 2 (PCV2): Pathogenesis and ...

    2019-5-8 · Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus–associated disease (PCVAD). The virus preferentially targets the lymphoid tissues, which leads to lymphoid depletion and immunosuppression in pigs. The disease is exacerbated by immunostimulation or concurrent infections with other pathogens. PCV2 resides in certain immune …

    Get Price
  • CIRCOVIRUS PORCINO PDF - anthonyshomestudio.com

    2021-1-28 · Porcine circovirus – Wikipedia. Colostrum samples were collected immediately after parturition and one day after farrowing. Comparisons of means were conducted using Duncan’s multiple range test. Multiple porcine circovirus 2 associated abortion and reproductive failure in a multiple-site swine production unit. Seventh report of the ICTV.

    Get Price
  • Proteomic Alteration of PK-15 Cells after Infection by ...

    2019-5-25 · Viral infections usually result in alterations in the host cell proteome which determine the fate of the infected cells and the progress of pathogenesis. To uncover cellular protein responses in classical swine fever virus-infected PK-15 cells, a proteomic analysis was conducted using 2D PAGE followed by MALDI-TOF-MS/MS identification. Altered expression of 35 protein spots in infected cells ...

    Get Price
  • US Patent for Method for porcine circovirus

    2016-5-13 · One embodiment of the invention is a method of producing circovirus in yields that may be useful, for example, the preparation of a vaccine, encompassing the steps of preparing PK15 cells for co-infection, infecting the PK15 cells with PCV2, culturing and expanding the PK15 cells through passages, and isolating, collecting or harvesting PCV2.

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  • Frontiers | Structure-Based Design of Porcine

    2016-10-15 · Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from post-weaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark[J]. Veterinary Microbiology, 2009,135(3-4):272-282.

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  • Circovirus Control | Swine Health

    2021-5-11 · Circovirus control. THE PCV2 VIRUS. Since the 1990's, the world has seen a dramatic increase in the porcine circovirus type 2 (PCV2) virus loads in pigs. This prolific virus impairs the immune system and leaves pigs susceptible to other swine diseases.

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  • Porcine Circovirus Type 2 (PCV2): Pathogenesis and ...

    2019-5-8 · Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus–associated disease (PCVAD). The virus preferentially targets the lymphoid tissues, which leads to lymphoid depletion and immunosuppression in pigs. The disease is exacerbated by immunostimulation or concurrent infections with other pathogens. PCV2 resides in certain immune …

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  • Novel porcine circovirus type 2b isolate and uses

    The present invention includes a short sequence replica, and is applied to the cell culture 10 The novel isolate can be useful for diagnosing particular pig unsealing nose virus type 2 (PCV2) production of a vaccine, pig CYR in the pig CYR pig, as well as the treatment and or prevention and or diagnosis of nasal virus accompanying diseases nose viruses .

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  • Identifying an outbreak of a novel swine disease using ...

    2012-10-16 · PRRSV infection presents with numerous and varied clinical signs in multiple age groups of pigs. This may explain why astute swine veterinarians regularly monitor client herds for PRRSV, and why swine disease outbreak investigations start with an examination for the presence of PRRSV . From a disease monitoring and surveillance point of view ...

    Get Price
  • US Patent for Method for porcine circovirus

    2016-5-13 · One embodiment of the invention is a method of producing circovirus in yields that may be useful, for example, the preparation of a vaccine, encompassing the steps of preparing PK15 cells for co-infection, infecting the PK15 cells with PCV2, culturing and expanding the PK15 cells through passages, and isolating, collecting or harvesting PCV2.

    Get Price
  • In Vitro Coinfection and Replication of Classical Swine ...

    2015-10-2 · Here, we investigated whether PCV2 and CSFV could infect the same cell productively by constructing an in vitro coinfection model. Our results indicated that PCV2-free PK15 cells but not ST cells were more sensitive to PCV2, and the PK15 cell line could stably harbor replicating CSFV (PK15-CSFV cells) with a high infection rate.

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  • Frontiers | Structure-Based Design of Porcine

    2019-5-25 · Viral infections usually result in alterations in the host cell proteome which determine the fate of the infected cells and the progress of pathogenesis. To uncover cellular protein responses in classical swine fever virus-infected PK-15 cells, a proteomic analysis was conducted using 2D PAGE followed by MALDI-TOF-MS/MS identification. Altered expression of 35 protein spots in infected cells ...

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  • Proteomic Alteration of PK-15 Cells after Infection by ...

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  • Describing antimicrobial use and reported treatment ...

    Significant differences in treatment failure among body systems affected likely reflected the etiology of common swine conditions. Many respiratory and multi-systemic conditions in swine have a viral etiology (e.g., porcine circovirus infection, influenza, PRRS) and antimicrobial treatment is not expected to resolve the primary viral infection.

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  • Replication of porcine circoviruses | Virology Journal ...

    2009-5-18 · The members of the Circovirus genus in the Circoviridae family are animal viruses, most of which affect birds although type 1 and type 2 porcine circoviruses (PCV-1 and PCV-2) affect swine and wild boars. All circoviruses known at present, except PCV-1, are associated with immuno-suppressive or immuno-depressive diseases. They have small (around 2 kb), closed-circular, single-stranded (ss) …

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  • Objective pathogen monitoring in nursery and finisher

    2020-9-8 · Porcine circovirus type 2 and S. suis type 2 were detected in all pens except for one, and PCV2 was present with Cq values below 16 in several of the pens with the majority in the finishers. Swine influenza A virus was detected in all age groups in the nurseries and was also detected in the beginning of the finisher period.

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  • Oral Fluids | Iowa State University

    2021-7-5 · Oral-fluid samples for surveillance of commercial growing pigs for porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 infections. J Swine Health Prod 16(2):86-91. 3. Hoffman P, Prickett J, Zimmerman J, et al. 2008. Implementation and validation of swine oral fluid collection in a commercial system.

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  • Immune evasion during foot-and-mouth disease virus ...

    2008-10-1 · African swine fever virus belongs to the Asfarviridae family and uses a different mechanism to evade immune surveillance. Within 10 h of infection, this virus induces alteration of the secretory pathway by interfering with the trans‐Golgi network (TGN).

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  • Porcine Circovirus Type 2 (PCV2): Pathogenesis and ...

    2013-1-1 · Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus–associated disease (PCVAD). The virus preferentially targets the lymphoid tissues, which leads to lymphoid depletion and immunosuppression in pigs. The disease is exacerbated by immunostimulation or concurrent infections with other pathogens. PCV2 resides in certain immune …

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  • Expression of human CD46 has no effect on porcine ...

    2012-3-3 · Read 'Expression of human CD46 has no effect on porcine circovirus type 2 infection and shedding in the experimental pig model, Veterinary Research Communications' on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at …

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  • Zoetis launches Europe's first dual PCV2 genotype pig ...

    2021-6-23 · Zoetis launches Europe's first dual PCV2 genotype pig vaccine. A new vaccine has been launched in Europe for pigs that will help tackle the ever-mutating porcine circovirus type 2 (PCV2). Over the past five to 10 years, the European swine industry has seen a significant dominance shift in its PCV2 strains from PCV2a to PCV2b and PCV2d now being ...

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  • PCVAD: When Immunology goes wrong, life on the

    PCV1 and PCV2 are the smallest known viruses that affect swine and are closely related to psittacine beak and feather disease circovirus. A number of circoviruses have been found that include canary, bovine, goose, columbid, ostrich, raven and a closely related TT virus, a circovirus found in humans that belongs to the Circoviridae family ...

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  • Frontiers | New Immunoinformatics Tools for Swine ...

    2020-10-5 · Novel computational tools for swine vaccine development can expand the range of immunization approaches available to prevent economically devastating swine diseases and spillover events between pigs and humans. PigMatrix and EpiCC are two new tools for swine T cell epitope identification and vaccine efficacy analysis that have been integrated into an existing computational …

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