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  • Tilmicosin enteric granules and premix to pigs ...

    2019-2-22 · The relative bioavailability of tilmicosin enteric granules to premix was 114.97 ± 7.19%, according to the AUC 0‐t values. These results demonstrated that tilmicosin enteric granules produced faster tilmicosin absorption, slower elimination, larger tissue distribution, and higher bioavailability compared to the tilmicosin premix.

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    The relative bioavailability of tilmicosin enteric granules to premix was 114.97 ± 7.19%, according to the AUC 0-t values. These results demonstrated that tilmicosin enteric granules produced faster tilmicosin absorption, slower elimination, larger tissue distribution, and higher bioavailability compared to the tilmicosin premix.

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  • Tilmicosin enteric granules and premix to pigs ...

    2019-2-22 · The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kin...

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  • Efficacy of enteric-coated tilmicosin granules in

    Background: Porcine infectious pleuropneumonia caused by Actinobacillus pleuropneumoniae (App) is one of the most serious infectious diseases in pigs and has brought huge economic losses to the world pig industry. The aim of this trial was to evaluate the effect of enteric-coated tilmicosin granule in the treatment and …

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    enteric -coated tilmicosin granules), LDG (Low dose entericcoated tilmicosin granules) and TPG (Tilmicosin premix drug control group). The cure rate, mortality, clinical respira-tory score, body temperature score, weight gain, lung score and so on were recorded. Results: The cure rate of HDG and MDG was as high as 90%, the …

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    Enteric-coated tilmicosin granules can cover up the bitterness of the drug itself and solve the problems caused by anorexia and poor palatability in sick pigs to a great extent. Previous studies in our laboratory have shown that enteric-coated tilmicosin granules provide higher relative bioavailability in pigs (AUC (0-t) −1 ·h; AUC (0-t) − ...

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  • Clinical field trials with tilmicosin phosphate in

    1996-2-1 · Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics. Xiong J, Zhu Q, Zhao Y, Yang S, Cao J, Qiu Y. J Vet Pharmacol Ther, 42(3):336-345, …

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  • Determination of antibacterial agent tilmicosin in

    The recoveries ranged from 95 to 99% for the three tested concentrations. The LC-MS/MS method described herein was simple, fast and less laborious than other methods, achieved high sensitivity using a small sample volume, and was successfully applied to pharmacokinetic studies of tilmicosin enteric granules after oral delivery to pigs.

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    2021-3-3 · Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics. J …

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  • Tilmicosin Phosphate (CAS No.:137330-13-3) -

    As shown in Table 3, the tilmicosin enteric granules were mildly sensitive to the high temperature of 40 °C. In the high light, 0.36% and 0.59% of the tilmicosin in the enteric granules were degraded after 5 d and 10 d, respectively. In the high humidity, 0.33% and 0.55% of tilmicosin in the granules was degraded after 5 d and 10 d, …

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  • Preparation, characterization, and

    2020-12-1 · Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to investigate the formulation’s characterization, stability, and effects in vitro/in …

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    2018-2-2 · 4. Sustained release enteric dissolution, fixed-point release, stronger drug efficacy: After enteric-coated tilmicosin enteric-coated granules through oral enteric-coated preparations, they are not released in the stomach, but are released slowly and slowly in the intestine, both to avoid drugs The stimulation of the …

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    2004-5-1 · Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics. Xiong J, Zhu Q, Zhao Y, Yang S, Cao J, Qiu Y. J Vet Pharmacol Ther, 42(3):336-345, …

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  • Preparation, characterization, and

    2021-7-3 · Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to investigate the formulation’s characterization, stability, and effects in vitro/in vivo.

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    2017-4-1 · Weaned pigs less than 14 weeks of age: For the reduction in incidence and overall severity of diarrhea in the presence of pathogenic Escherichia coli in groups of weaned pigs: Feed as the sole ration for 21 consecutive days. To assure responsible antimicrobial drug use in pigs, do not administer to pigs 14 weeks of …

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  • [PDF] Intracellular accumulation, subcellular

    Tilmicosin is a semi-synthetic macrolide antibiotic, currently approved for veterinary use in cattle and swine respiratory disease, and is in development for use in poultry mycoplasma air sacculitis. In order to provide an understanding of clinical efficacy, the in vitro interaction of tilmicosin with three types of chicken phagocytes (MQ …

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  • Intracellular accumulation, subcellular distribution,

    Tilmicosin is a semisynthetic macrolide antibiotic currently approved for veterinary use in cattle and swine to combat respiratory disease. Because the concentrations of tilmicosin are generally low in bovine serum, the interaction of tilmicosin with three types of bovine phagocytes (monocyte-macrophages, macrophages, and …

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    2020-3-1 · Tilmicosin enteric granules and premix to pigs: antimicrobial susceptibility testing and comparative pharmacokinetics, J. Vet Pharmacol. Ther. , …

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  • Pharmacokinetics of tilmicosin in healthy pigs and

    2017-12-1 · A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by …

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    The invention discloses a tilmicosin solid dispersible granule as well as a preparation method and an application thereof. The tilmicosin solid dispersible granule consists of tilmicosin and a carrier accessory. The carrier accessory is one of glycerin monostearate, stearyl alcohol, saturated triglyceride, glycerinum simple lipid, …

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    For the treatment and control of swine dysentery (vibrionic dysentery, bloody scours), salmonellosis (necrotic enteritis), enteritis associated with E.coli and as an aid in control of mycoplasmal pneumonia. As an aid in the maintenance of efficient feed conversion ratios and rates of gain in the presence of M. hyopneumoniae, M. …

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  • Efficacy of tilmicosin in the control of

    2004-1-1 · Europe PMC is an archive of life sciences journal literature. The efficacy of tilmicosin administered in the feed to control Actinobacillus pleuropneumoniae infections in pigs was evaluated through a multisite, multitrial study. For each of 6 trials, 48 pigs (stratified by weight and sex) were randomly assigned to 6 to 8 pens.

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    Weaned pigs less than 14 weeks of age: For the reduction in incidence and overall severity of diarrhea in the presence of pathogenic Escherichia coli in groups of weaned pigs: Feed as the sole ration for 21 consecutive days. To assure responsible antimicrobial drug use in pigs, do not administer to pigs 14 weeks of age or older: …

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    2017-6-30 · Aivlosin is a highly effective antibiotic that treats a range of specific enteric (gut) and respiratory diseases in pigs and poultry, ensuring a rapid return to health. In addition to the welfare benefits, healthy animals gain weight faster, digest food more efficiently and get to market earlier which all bring economic benefit to …

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    For use as an aid in stimulating growth and improving feed efficiency in pigs and as an aid in controlling enteric diseases caused by organisms susceptible to tylosin in pigs. For the treatment and prevention of ileitis in pigs. ... Liquid vitamin premix for poultry cattle, swine, rabbits and horses. × ... Ready-to-use fly bait granules for ...

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  • The anti-nociceptive potential of tilmicosin

    2015-10-30 · Tilmicosin is structurally related to tylosin, having the chemical formula (C 46 H 80 N 2 O 13) with a molecular weight of 869.15.Physically, it is freely soluble (1500 mg/L or greater) in organic solvents (hexane, acetone, acetonitrile, chloroform, dichloromethane, ethyl acetate, methanol, tetrahydrofuran); water solubility is …

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    2019-8-26 · The aim of the present study was to assess the analgesic activity of the macrolide antibiotic tilmicosin at dose levels of 20 and 40 mg/kg of body weight, subcutaneously, against chemical- and ther...

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    Aivlosin is a highly effective antibiotic that treats a range of specific enteric (gut) and respiratory diseases in pigs and poultry, ensuring a rapid return to health. In addition to the welfare benefits, healthy animals gain weight faster, digest food more efficiently and get to market earlier which all bring economic benefit to the farmer.

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    2017-8-31 · For all pigs; 1 Pigs should be kept as much as possible in stable social groups, and mixing at any stage between accommodation types should be kept to a minimum. 2 Avoid mixing in pens where sharp edges to feed troughs and drinkers protrude, and can injure the pigs. 3 Always mix pigs of similar size. 4 As a general …

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    Technical details about Tilmicosin, learn more about the structure, uses, toxicity, action, side effects and more. ... > is available as an injectable formulation for the treatment of respiratory diseases in cattle and sheep and as a feed premix for the treatment and control of respiratory diseases in pigs.

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    Weaned pigs less than 14 weeks of age: For the reduction in incidence and overall severity of diarrhea in the presence of pathogenic Escherichia coli in groups of weaned pigs: Feed as the sole ration for 21 consecutive days. To assure responsible antimicrobial drug use in pigs, do not administer to pigs 14 weeks of age or older: …

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