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comparative pharmacokinetics of florfenicol outporters

  • Comparative pharmacokinetics of florfenicol in

    Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight.

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  • Comparative pharmacokinetics of florfenicol in the

    1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance …

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  • Comparative pharmacokinetics of two florfenicol ...

    2019-10-24 · OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep. ANIMALS 16 healthy adult mixed-breed sheep. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC. After a 2-week washout period, each sheep …

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  • Comparative plasma pharmacokinetics and tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats. The concentration of florfenicol in plasma was determined ...

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  • Comparative pharmacokinetics of florfenicol in

    2019-3-25 · As a result, the area under the concentration curve for 0–12 hr (AUC 0–12 hr) for FF in healthy ducks was significantly greater than that in infected ducks (49.47 ± 5.31 vs. 34.52 ± 8.29 μg hr/ml). The pharmacokinetic differences of FF in lung tissues between the two groups correlated with the serum pharmacokinetic differences.

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  • Comparative pharmacokinetics of florfenicol in

    2019-3-25 · Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF ) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight.

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  • Comparative pharmacokinetics of florfenicol in the

    2009-1-1 · Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Fan G, Zhang L, Shen Y, Shu G, Yuan Z, Lin J, Zhang W, Peng G, Zhong Z, Yin L, Fu H

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  • Comparative muscle irritation and pharmacokinetics

    Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic.

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  • Comparative single-dose pharmacokinetics of orally ...

    The MICs of florfenicol were 1.2 μg/ml and 5 μg/ml against L. garviae and S. iniae, respectively. Healthy fish showed higher values for most of the PK/PD parameters as compared to fish infected with L. garvieae which was reversed in fish infected with S. iniae.

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  • Comparative muscle irritation and pharmacokinetics

    2019-11-13 · Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in …

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  • Comparative pharmacokinetics of florfenicol in

    Article “Comparative pharmacokinetics of florfenicol in Japanese eels at different temperature” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology information which hitherto ...

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  • Comparative pharmacokinetics of antisense

    The present study provides a comparative understanding of florfenicol deposition kinetics following oral administration at a single dose of 30 mg kg body weight to Japanese eel( Anguilla japonica) at the temperature of 20℃,24℃ and 28℃,respectively.

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  • Comparative pharmacokinetics of purified flaxseed

    Comparative pharmacokinetics of florfenicol powder with two different preparation technology (Shandong New Hope Liuhe Group Co., Ltd) Abstract: Twenty healthy broilers were randomly divided into two groups: group A and group B. 20% florfenicol powder was ...

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  • Preparation, characterisation and antibacterial activity ...

    Antisense oligonucleotides have attracted special interest as a novel class of therapeutic agents for the treatment of viral infection, cancers, and genetic disorders because of their ablhty to inhibit expression of a disease-associated gene in a sequence-specific manner. Gene expression is inhibite …

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  • Comparative pharmacokinetics of florfenicol after ...

    A single dose of florfenicol (Nuflor, 20 mg/kg b.w.) was injected either i.v., i.m. or s.c. respectively, in 3 groups of apparently healthy sheep (5 animals each) to compare its pharmacokinetic properties. The drug concentrations in serum samples were measured for 24 h using HPLC with fluorescence detection. There was a rapid absorption for the drug reaching maximum serum concentrations (4.86 ...

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  • Comparative Pharmacokinetics of Tylosin or

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , …

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  • Comparative pharmacokinetics of two florfenicol ...

    OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep. ANIMALS 16 healthy adult mixed-breed sheep. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC.

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  • Comparative pharmacokinetics of florfenicol in the

    1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance …

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  • Comparative plasma pharmacokinetics and tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats.

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  • Pharmacokinetics of florfenicol and its metabolite ...

    2008-2-1 · Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats Vet. Res. Commun. , 27 ( 2003 ) , pp. 475 - 483 View Record in Scopus Google Scholar

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  • Temperature-dependent pharmacokinetics of

    2019-3-30 · Comparative pharmacokinetics of florfenicol in Japanese eels at different temperature Anim. Husb. Feed Sci. , 7 ( 2015 ) , pp. 126 - 130 View Record in Scopus Google Scholar

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  • FLORFENICOL PHARMACODYNAMIC,

    2006-6-16 · florfenicol oral forms, they should be considered as a powerful tool for combating complex infections that are frequently met in intensive ani-mal production. Key words: florfenicol, oral forms, pharmacokinetics, pharmacody-namics, systematic review, pigs Florfenicol is a thiamphenicol derivative whose molecule contains a

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  • [PDF] Pharmacokinetics and Bioequivalence of

    A pharmacokinetic and bioequivalence evaluation of two florfenicol oral solutions was carried out in 28 healthy broiler chickens after oral administration of a single dose of 20 mg/kg bw, according to a randomized, parallel experimental design. The two formulations were: Flonicol® (Mobedco, Jordan) as a test product and Veterin®10% (Centrovet, Chile) as a reference product.

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  • [PDF] Pharmacokinetics of florfenicol in cod Gadus

    The pharmacokinetic profile of the antibacterial agent florfenicol was studied in plasma after intravenous (i.v.) injection and in plasma, muscle and liver following oral (p.o.) administration to cod Gadus morhua, held in seawater at 8 degrees C and weighing 100 to 200 g. Following i.v. injection, the plasma drug concentration-time profile showed 2 distinct phases.

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  • Comparative pharmacokinetics of two florfenicol ...

    OBJECTIVE To compare the pharmacokinetics of 2 commercial florfenicol formulations following IM and SC administration to sheep. ANIMALS 16 healthy adult mixed-breed sheep. PROCEDURES In a crossover study, sheep were randomly assigned to receive florfenicol formulation A or B at a single dose of 20 mg/kg, IM, or 40 mg/kg, SC.

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  • Comparative Pharmacokinetics of Tylosin or

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , …

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  • Comparative pharmacokinetics of florfenicol in the

    1. The pharmacokinetics of florfenicol were investigated in chickens (n = 20), pigeons (n = 30) and quails (n = 60) following intravenous (i.v.) and intramuscular (i.m.) administration of 30 mg/kg body weight. The concentration of florfenicol was measured using high performance …

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  • Comparative plasma pharmacokinetics and tolerance

    Florfenicol, a monofluorinated analogue of thiamphenicol, has a broad antibacterial spectrum. The pharmacokinetics of florfenicol was studied following a single intravenous (i.v.) or intramuscular (i.m.) injection at a dose of 20 mg/kg body weight in healthy male camels, sheep and goats.

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  • Comparative Plasma Pharmacokinetics and Tolerance

    2004-10-8 · Read 'Comparative Plasma Pharmacokinetics and Tolerance of Florfenicol following Intramuscular and Intravenous Administration to Camels, Sheep and Goats, Veterinary Research Communications' on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

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  • [PDF] Pharmacokinetics and Bioequivalence of

    A pharmacokinetic and bioequivalence evaluation of two florfenicol oral solutions was carried out in 28 healthy broiler chickens after oral administration of a single dose of 20 mg/kg bw, according to a randomized, parallel experimental design. The two formulations were: Flonicol® (Mobedco, Jordan) as a test product and Veterin®10% (Centrovet, Chile) as a reference product.

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  • [PDF] Pharmacokinetics of florfenicol following ...

    Florfenicol is a synthetic broad-spectrum antibiotic used to treat infectious diseases in veterinary medicine. Limited information is available on the pharmacokinetics and bioavailability of florfenicol in dogs. This study was conducted in six healthy dogs to determine the bioavailability and pharmacokinetics of florfenicol following a single intravenous ( i.v.) and intramuscular ( i.m.) dose ...

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  • [PDF] Pharmacokinetics of florfenicol in cod Gadus

    The pharmacokinetic profile of the antibacterial agent florfenicol was studied in plasma after intravenous (i.v.) injection and in plasma, muscle and liver following oral (p.o.) administration to cod Gadus morhua, held in seawater at 8 degrees C and weighing 100 to 200 g. Following i.v. injection, the plasma drug concentration-time profile showed 2 distinct phases.

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  • Pharmacokinetic parameters and optimal dosage of a ...

    The aims of this study were to evaluate the in vitro antibacterial activity of a florfenicol and tylosin mixture and to determine the pharmacokinetic parameters of each drug following administration of the 2 : 1 florfenicol and tylosin mixture in beagle dogs. The antibacterial activity of the two antibiotics, both singly and as a mixture, was investigated in bacteria isolated from 119 beagle dogs.

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  • Comparative single-dose pharmacokinetics of four ...

    Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C.

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  • Comparative Pharmacokinetics of Tylosin or

    Comparative Pharmacokinetics of Tylosin or Florfenicol after a Single Intramuscular Administration at Two Different Doses of Tylosin-Florfenicol Combination in Pigs Mi-Hee KIM , Elias GEBRU , Zhi-Qiang CHANG , Jae-Young CHOI , Mi-Hyun HWANG , Eun-Hee KANG , …

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  • Pharmacokinetics of florfenicol after intravenous and ...

    2009-8-1 · Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats Vet. Res. Commun. , 27 ( 2003 ) , pp. 475 - 483 View Record in Scopus Google Scholar

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  • Pharmacokinetics of florfenicol and its metabolite ...

    The pharmacokinetics of florfenicol (FF) and its metabolite, florfenicol amine (FFA), were studied in rice field eel (Monopterus albus) after a single dose (20 mg/kg) by intramuscular (i.m.) or oral gavage (p.o.) dose at 25 °C. The elimination half-lives (t1/2β ), peak concentration of FF (Cmax ), and time to reach FF peak concentration (Tmax ) in plasma were estimated as 18.39 h, 10.83 μg ...

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  • [PDF] Pharmacokinetics of florfenicol following ...

    Florfenicol is a synthetic broad-spectrum antibiotic used to treat infectious diseases in veterinary medicine. Limited information is available on the pharmacokinetics and bioavailability of florfenicol in dogs. This study was conducted in six healthy dogs to determine the bioavailability and pharmacokinetics of florfenicol following a single intravenous ( i.v.) and intramuscular ( i.m.) dose ...

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  • Pharmacokinetics of florfenicol in healthy and

    2002-10-1 · The pharmacokinetics of florfenicol were studied in both healthy (n=9) and Escherichia coli-infected (n=27) broiler chickens following intravenous (i.v.), intramuscular (i.m.) and oral administration at a single dose of 30 mg/kg bw.Infection was induced artificially in broiler chickens (35 d) by an intraperitoneal injection with 1.3×10 9 colony-forming units of E. coli.

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  • Pharmacokinetics of florfenicol in serum and synovial ...

    2019-10-24 · Objective—To define the pharmacokinetics of florfenicol in synovial fluid (SYNF) and serum from central venous (CV) and digital venous (DV) blood samples following regional IV perfusion (RIVP) of the distal portion of the hind limb in cows.. Animals—6 healthy adult cows.. Procedures—In each cow, IV catheters were placed in the dorsal common digital vein (DCDV) and the plantar vein of the ...

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  • Comparative pharmacokinetics of oxytetracycline in

    2018-10-1 · Comparative pharmacokinetics of oxytetracycline in tilapia (Oreochromis spp.) maintained at three different salinities. ... Feng et al. (2008) demonstrated that florfenicol tissue drug concentrations of seawater tilapia were lower than that in freshwater tilapia; and the elimination of florfenicol in seawater tilapia was more rapid than that in ...

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  • Comparative single-dose pharmacokinetics of four ...

    Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C.

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  • Temperature-dependent non-linear pharmacokinetics

    2020-2-25 · Comparative pharmacokinetics of florfenicol in Japanese eels at different temperature. Anim Husb Feed Sci., 7 (2015), pp. 126-130. View Record in Scopus Google Scholar. Liu et al., 2009. Y.T. Liu, X.H. Ai, H. Yang. Pharmacokinetics of florfenicol in channel …

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  • Frontiers | Comparative Pharmacokinetics of

    2020-9-8 · Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum vs. Mid-lactation Dairy Cattle Rochelle Warner 1 , Joshua A. Ydstie 1 , Larry W. Wulf 2 , Ronette Gehring 3 , Johann F. Coetzee 4 , Jonathan P. Mochel 1,5 and Patrick J. Gorden 1 *

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  • Pharmacokinetics of Florfenicol in the Red Pacu

    2021-7-6 · In rainbow trout (Oncorhynchus mykiss) kept at 10°C, an oral dose of 10 mg/kg had a mean residence time of 21 hours and a C MAX of 3.23 mcg/ml. 10 Pharmacokinetics have also been described for Atlantic salmon, Salmo salar. 11 Because chloramphenicol pharmacokinetics vary among animal species, a similar pattern was expected for florfenicol. 12 ...

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  • Pharmacokinetics and tissue depletion of florfenicol in ...

    2010-10-1 · Florfenicol (Ff) is a synthetic antibiotic with a broad antibacterial spectrum and high therapeutic effectiveness that was specifically developed for veterinary use. In the present study, tissue residual levels and the pharmacokinetics of Ff after oral administration of 30 mg/kg to Leghorn and Taiwan Native chicken were studied.

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  • Pharmacokinetics of florfenicol in serum and synovial ...

    2019-10-24 · Objective—To define the pharmacokinetics of florfenicol in synovial fluid (SYNF) and serum from central venous (CV) and digital venous (DV) blood samples following regional IV perfusion (RIVP) of the distal portion of the hind limb in cows.. Animals—6 healthy adult cows.. Procedures—In each cow, IV catheters were placed in the dorsal common digital vein (DCDV) and the plantar vein of the ...

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  • Pharmacokinetics and tolerance of florfenicol in

    1996-5-1 · Pharmacokinetics and tolerance of florfenicol in Equidae Pharmacokinetics and tolerance of florfenicol in Equidae MCKELLAR, Q. A.; VARMA, K. J. 1996-05-01 00:00:00 Q. A. MCKELLAR* and K. J. VARMAt Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 lQH, UK and &hering-Plough Animal Health, PO Box 3182,Union, New Jersey …

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  • Pharmacokinetic Study of Florfenicol in Healthy and

    2015-12-31 · Abstract The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of 20mg{cdot}kg^{-1} at 25{pm}2^{circ}C.After oral administration ...

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  • Florfenicol for Chickens and Ducks - PoultryDVM

    Wang, Xiao, et al. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers Ecotoxicology and Environmental Safety 207 (2021) Ismail, M., and Y. A. El-Kattan. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. British poultry science 50.1 (2009); hen, J., et al. Bioavailability and pharmacokinetics of florfenicol in broiler ...

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  • Multidose pharmacokinetics of orally administered ...

    2013-10-1 · The pharmacokinetics of florfenicol observed in this multiple dose study support its label claim for control of mortality associated with E. ictaluri and F. columnare , and the plasma values in catfish exceed the florfenicol MIC values for these pathogens when administered at 10 mg/kg bw one time a day for 10 days.

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  • Frontiers | Multi-Component Comparative

    2020-6-19 · Citrus × aurantium L., Chinese name: Fructus Aurantii (FA) has been largely used as Qi-invigorating herb in China for centuries. The main components (meranzin hydrate, naringin, neohesperidin, meranzin, nobiletin) have good physiological activity with relatively high abundance in FA. Few multi-component comparative pharmacokinetics are simultaneously accessible for the flavone …

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  • A comparative study of the minimum inhibitory and

    A comparative reference range was not available as enrofloxacin is not registered in South Africa for use in horses, and is used extra-labelly. The results for florfenicol against P. multocida yielded an MIC50 value of 0.5 µg/ml and an MPC50 value of <2 µg/ml. The close relationship of these two concentrations

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  • Comparative Pharmacokinetics of Enrofloxacin After ...

    'Comparative Pharmacokinetics of Enrofloxacin After SubcutaneousAdministration of a Novel in situ Gel Forming Preparation and aConventional Product to Rabbits', Iranian Journal of Veterinary Medicine, 15(1), pp. 68-78. doi: 10.22059/ijvm.2020.295087.1005057

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  • Pharmacokinetics of Florfenicol in the Red Pacu

    2021-7-6 · In rainbow trout (Oncorhynchus mykiss) kept at 10°C, an oral dose of 10 mg/kg had a mean residence time of 21 hours and a C MAX of 3.23 mcg/ml. 10 Pharmacokinetics have also been described for Atlantic salmon, Salmo salar. 11 Because chloramphenicol pharmacokinetics vary among animal species, a similar pattern was expected for florfenicol. 12 ...

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  • Pharmacokinetic Study of Florfenicol in Healthy and

    2015-12-31 · Abstract The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of 20mg{cdot}kg^{-1} at 25{pm}2^{circ}C.After oral administration ...

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  • Pharmacokinetic of florfenicol in pulmonary epithelial ...

    A.A.; HASHAAD, M. Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats. Vet. Res.

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  • Florfenicol pharmacokinetics in lactating cows after ...

    Pharmacokinetics of florfenicol 30% injectable solution was determined in lactating cows after intravenous, intramammary and intramuscular administration. Serum concentration-time data generated in the present study were analysed by non-compartmental methods based on statistical moment theory.

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  • Florfenicol - pharmacodynamic, pharmacokinetics and ...

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective …

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  • Florfenicol for Chickens and Ducks - PoultryDVM

    Wang, Xiao, et al. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers Ecotoxicology and Environmental Safety 207 (2021) Ismail, M., and Y. A. El-Kattan. Comparative pharmacokinetics of florfenicol in the chicken, pigeon and quail. British poultry science 50.1 (2009); hen, J., et al. Bioavailability and pharmacokinetics of florfenicol in broiler ...

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  • Multidose pharmacokinetics of orally administered ...

    2013-10-1 · The pharmacokinetics of florfenicol observed in this multiple dose study support its label claim for control of mortality associated with E. ictaluri and F. columnare , and the plasma values in catfish exceed the florfenicol MIC values for these pathogens when administered at 10 mg/kg bw one time a day for 10 days.

    Get Price
  • In vivo pharmacokinetic/Pharmacodynamic modeling

    2018-11-29 · Koc F, Uney K, Ozturk M, Kadioglu Y, Atila A. Pharmacokinetics of florfenicol in the plasma of Japanese quail. N Z Vet J. 2009;57(6):388–91. CAS Article Google Scholar 13. Aliabadi FS, Ali BH, Landoni MF, Lees P. Pharmacokinetics and PK-PD modelling of …

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  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum. Ole Samuelsen. ø. Bergh. Ole Samuelsen. ø. Bergh. Related Papers. Efficacy of orally administered flumequine in the treatment of vibriosis caused by …

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  • A comparison of florfenicol and tilmicosin for the ...

    Adams PE, Varma KJ, Powers TE, Lamendola JF. Tissue concentrations and pharmacokinetics of florfenicol in male veal calves given repeated doses. Am J Vet Res. 1987 Dec; 48 (12):1725–1732. Hoar BR, Jelinski MD, Ribble CS, Janzen ED, Johnson JC.

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  • Florfenicol - pharmacodynamic, pharmacokinetics and ...

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective …

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  • Tissue pharmacokinetics of florfenicol in pigs ...

    The aim of this study has been to determine the tissue pharmacokinetic parameters of florfenicol in the pigs experimentally infected with Actinobacillus pleuropneumoniae. 21 crossed-bred (Duroc × Landrace × Yorkshire) local species of pigs were infected experimentally with Actinobacillus pleuropneumoniae serotype 1 and confirmed as typical sub-acute pleuropneumonia.

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  • Comparative bioavailability between two routes of ...

    2011-7-29 · Florfenicol is a broad-spectrum time-dependent antimicrobial agent. Florfenicol is indicated in the treatment of bacterial pneumonia and associated respiratory infections in cattle and swine [1, 2]. The recommended dosage regimen for bovine is either a single dose of 40 mg/kg BW by SC route or two doses of 20 mg/kg BW by IM route with an ...

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  • In vivo pharmacokinetic/Pharmacodynamic modeling

    2018-11-29 · Koc F, Uney K, Ozturk M, Kadioglu Y, Atila A. Pharmacokinetics of florfenicol in the plasma of Japanese quail. N Z Vet J. 2009;57(6):388–91. CAS Article Google Scholar 13. Aliabadi FS, Ali BH, Landoni MF, Lees P. Pharmacokinetics and PK-PD modelling of …

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  • Article | Veterinární medicína

    Ali BH, Al-Qarawi AA, Hashaad M (2003): Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats. Veterinary Research Communications 27, 475–483.

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  • Development and validation of a method for

    2021-3-30 · Florfenicol is a chloramphenicol antibiotic that plays an essential role on bacteriostasis. Long-term use of florfenicol in livestock and poultry can cause immunetoxicity and reproductive toxicity and the consumption of animal-derived products with excessive residues of florfenicol will pose a certain threat to human health. To study residue depletion of oral florfenicol in chickens, 48 ...

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  • Pharmacokinetics of lincomycin following ...

    2016-7-25 · Comparative pharmacokinetics of antibiotics in new born calves: chloramphenicol, lincomycin and tylosin, American Journal of Veterinary Research, 44: 1053-1057. Chaleva, E. and Nquyen, D. L., (1987). Pharmacokinetic research on Pharmachem’s lincomycin hydrochloride in pigs, Veterinarno Meditsinski Nauki, 24: 47-51.

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  • Antibacterial Agents in Mediterranean Finfish

    The literature pertaining to the use of registered antibacterial agents in Mediterranean finfish farming is reviewed, with an emphasis on the Greek fish-farming industry. This review provides a scientific resource dedicated to the design of future antibacterial dosing regimes in Mediterranean fish farming, where insufficient supporting information is currently available.

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  • Pharmacokinetics of Florfenicol in Healthy Pigs and in ...

    Florfenicol is a novel antibiotic for use only with animals that belongs to the chloramphenicol family. Florfenicol has a mechanism for inhibiting the protein synthesis of susceptible bacteria by combining simultaneously with the 50S and 70S subunits in the ribosome to abolish the activity of peptidyl transferase (5, 7).

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  • e q u i v a lence Journal of Abu-Basha et al., J Bioequiv ...

    2019-11-11 · the pharmacokinetics and bioavailability of florfenicol have been investigated in broiler chickens [15-17], turkeys [7] and ducks [18]. Most of these studies used the same original preparation of florfenicol. There is therefore little information available regarding the differences between formulations of florfenicol used in poultry.

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  • Tissue pharmacokinetics of florfenicol in pigs ...

    The aim of this study has been to determine the tissue pharmacokinetic parameters of florfenicol in the pigs experimentally infected with Actinobacillus pleuropneumoniae. 21 crossed-bred (Duroc × Landrace × Yorkshire) local species of pigs were infected experimentally with Actinobacillus pleuropneumoniae serotype 1 and confirmed as typical sub-acute pleuropneumonia.

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  • (PDF) Pharmacokinetics of florfenicol in cod Gadus

    Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum. Ole Samuelsen. ø. Bergh. Ole Samuelsen. ø. Bergh. Related Papers. Efficacy of orally administered flumequine in the treatment of vibriosis caused by …

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  • Comparative bioavailability between two routes of ...

    2011-7-29 · Florfenicol is a broad-spectrum time-dependent antimicrobial agent. Florfenicol is indicated in the treatment of bacterial pneumonia and associated respiratory infections in cattle and swine [1, 2]. The recommended dosage regimen for bovine is either a single dose of 40 mg/kg BW by SC route or two doses of 20 mg/kg BW by IM route with an ...

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  • Florfenicol pharmacokinetics following intravenous

    Concentrations of florfenicol in oral administration (medicated feed route) were significantly higher than concentrations of florfenicol in bath route in plasma and ... Florfenicol pharmacokinetics following intravenous and oral administrations and its elimination after oral and bath administrations in common carp (Cyprinus carpio) #antibiotic.

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  • DOISerbia - Florfenicol - pharmacodynamic ...

    Florfenicol - pharmacodynamic, pharmacokinetics and clinical efficacy of oral formulations in domestic animals: A systematic review Ščuka Leon (Krka d.d., Novo mesto, Ljubljana, Slovenija) Porcine respiratory disease complex (PRDC) is a major economic problem for swine producers world-wide.

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  • (PDF) Pharmacokinetic–pharmacodynamic integration

    Pharmacokinetic–pharmacodynamic integration and modelling of florfenicol in calves. Ali Rassouli. Tiffany Potter. Andrew Rycroft. Pritam Sidhu. Ali Rassouli. Tiffany Potter. Andrew Rycroft. Pritam Sidhu. Download PDF. Download Full PDF Package. This paper. A short summary of this paper.

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  • Frontiers | VetCAST Method for Determination of the ...

    The elimination of gentamicin residues in eggs was reported by Filazi et al. 8 . When administered to laying hens via IM or SC routes, gentamicin was deposited in egg yolk and albumen, with residues persisting for longer periods in the yolk 8,9 .Although the aminoglycosides have been extensively reviewed, few studies on the pharmacokinetics of ...

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  • Pharmacokinetics of Florfenicol in Healthy Pigs and in ...

    Florfenicol is a novel antibiotic for use only with animals that belongs to the chloramphenicol family. Florfenicol has a mechanism for inhibiting the protein synthesis of susceptible bacteria by combining simultaneously with the 50S and 70S subunits in the ribosome to abolish the activity of peptidyl transferase (5, 7).

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  • e q u i v a lence Journal of Abu-Basha et al., J Bioequiv ...

    2019-11-11 · the pharmacokinetics and bioavailability of florfenicol have been investigated in broiler chickens [15-17], turkeys [7] and ducks [18]. Most of these studies used the same original preparation of florfenicol. There is therefore little information available regarding the differences between formulations of florfenicol used in poultry.

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  • Florfenicol - pharmacodynamic, pharmacokinetics and ...

    Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated. For this purpose the systematic review and meta-analysis were done. In vitro efficacy of florfenicol showed that this drug is highly effective …

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  • Florfenicol pharmacokinetics following intravenous

    Concentrations of florfenicol in oral administration (medicated feed route) were significantly higher than concentrations of florfenicol in bath route in plasma and ... Florfenicol pharmacokinetics following intravenous and oral administrations and its elimination after oral and bath administrations in common carp (Cyprinus carpio) #antibiotic.

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  • DOISerbia - Florfenicol - pharmacodynamic ...

    Florfenicol - pharmacodynamic, pharmacokinetics and clinical efficacy of oral formulations in domestic animals: A systematic review Ščuka Leon (Krka d.d., Novo mesto, Ljubljana, Slovenija) Porcine respiratory disease complex (PRDC) is a major economic problem for swine producers world-wide.

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  • Frontiers | Comparative Pharmacokinetics and

    2008-12-15 · Lashev, L. & D. J. Dimitrova, 2008. Comparative allometric analysis of three isoxa-zolylpenicillins in four mammalian species. Bulg. J. Vet. Med., 11, No 4, 269 −273. Comparative allometric analysis of selected pharmacokinetic parameters of cloxacillin, dicloxacillin and flucloxacillin in four animal species (cats, dogs, pigs and sheep) was ...

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  • Short communication COMPARATIVE ALLOMETRIC

    Comparative pharmacokinetics of theophylline and ethylenediamine following single and repeated doses of a sustained-release aminophylline preparation to volunteers. Journal of Pharmacy and Pharmacology, 1985. Badreldin Ali. Download PDF. Download Full PDF Package. This paper.

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  • (PDF) Comparative pharmacokinetics of theophylline

    2015-4-1 · Praziquantel (PZQ) is an effective pesticide against monogeneans. Its pharmacokinetics in fish may be affected by water environment and temperature. The present study was designed to compare the pharmacokinetics, tissue distribution, and elimination of PZQ in freshwater-acclimated grass carp and brackish water cultured grass carp. Plasma and tissue PZQ concentrations were determined after a ...

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  • Comparison of praziquantel pharmacokinetics and

    2018-10-24 · The aim of this study was to optimize the dosage regimen of tylosin against S.suis in Pigs using pharmacokinetic-pharmacodynamic (PK-PD) modeling. The antibacterial activity of tylosin against S.suis CVCC606 was investigated in Mueller Hinton (MH) broth and serum. The objectives of this investigation were to study the PD data of tylosin against S.suis CVCC606 and the PK data of tylosin …

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